Testing blood and spinal fluid for:

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• Antithyroid autoantibodies including Thyroid Peroxidase Antibody (TPO) or Thyroglobulin Antibody (TgAb)

 

• Thyroid and Stimulating Hormone Receptor Antibody (TRAb)

 

• Check for the presence of other antibodies associated with cognitive or psychiatric symptoms such as Anti-NMDA Receptor (NMDAR) encephalitis or other AE's. (See here)

 

• Vital lab tests to rule out life-threatening or debilitating conditions such as viral or bacterial encephalitis, meningitis or Creutzfedt-Jakov disease. 

 

• Check for presence of inflammation markers such as C-reactive protein or erythrocyte sedimentation rate (ESR)

 

• Protein levels

 

• Glucose levels

 

• Oligoclonal bands

 

• Opening pressure in the CSF

 

• Checked for significant vitamin deficiency

 

• Presence of heavy metals

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PET or SPECT scans to look for hypoperfusion or hypometabolism

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MRI to check for evidence of physical damage to brain

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EEG to look for evidence of seizure-activity or of noticeable slight slowing

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Neuropsychological testing to objectively identify specific areas and degrees of impairment.